Associations between patterns of wild ungulate patch use, soil carbon and albedo in montane grasslands
- Authors: Mc Gregor, Steven
- Date: 2024-12
- Subjects: Grassland ecology , Global environmental change , Climatic changes
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/69382 , vital:77250
- Description: Grassy ecosystems are essential for human survival, providing key services including food production, water provisioning and moderating climate. Yet, grassy ecosystems remain undervalued due to misconceptions that they are remnants of degraded states of forest – a view that continues to influence climate change policies. This thesis explores the links between wild, free-roaming ungulate grazers and climate drivers, including carbon storage and surface albedo (i.e., reflectance of solar radiation), through their impacts on vegetation and soils. Using black wildebeest (Connochaetes gnou) as a model wild species, I compared their grazing patterns in an Afromontane grassland in the eastern Karoo, South Africa, to those of short-duration cattle grazing systems in similar nearby grasslands (Chapter 2). While short-duration grazing aims to mimic spatiotemporal wild ungulate grazing patterns to supposedly enhance ecosystem functioning and soil carbon stocks, I found that wildebeest had ~50% shorter grazing durations and much shorter rest intervals (1-5 days versus 60-365 days), revealing key differences in grazing patterns that may affect vegetation and climate feedbacks. Next, I examined spatial variations in soil organic carbon (SOC) stocks between grass growth forms that differ in grazing tolerance (Chapter 3). Red grass (Themeda triandra) tussock patches, sensitive to frequent grazing, had higher SOC to a soil depth of 20 cm (61.45 ± 1.59 Mg C·ha-1)than intensively grazed, prostrate-growing Cynodon dactylon grazing lawns (55.43 ± 3.40Mg C·ha-1), likely due to greater shading and soil moisture beneath tussocks which drives microbial decomposition. Seasonal albedo variations were then assessed across distinct grassland patch types among seasons to determine whether albedo varies seasonally at fine patch-scales between grass patches, between shrub and grass patches, and with grazing (Chapter 4). Albedo was lower during the growing season compared to dormancy, and was consistently lower in dwarf shrub (Pentzia incana) encroached patches compared to grass patches. No albedo differences between grazed and less-grazed tussock grass patches of the same species were found, although intensively grazed grazing lawns had consistently higher albedo than most patch types. Finally, I evaluated trade-offs between plant carbon, albedo, and their impacts on radiative forcing (i.e., atmospheric warming/cooling) resulting from patch type changes commonly found in grassy ecosystems (Chapter 5). The loss of perennial grass cover resulted in the highest net positive (warming) effect, mostly due to reduced root biomass. Additionally, shrub encroachment into all patches lowered albedo, but led to negative (cooling) effects from shrub encroachment into bare ground patches due to biomass gains. This thesis challenges current views of grassy landscapes and short-duration grazing systems, emphasizing the need to rethink climate change mitigation strategies to prioritize maintaining heterogeneity, while enhancing carbon sequestration and albedo in grassy ecosystems. , Thesis (PhD) -- Faculty of Science, School of Environmental Sciences, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Mc Gregor, Steven
- Date: 2024-12
- Subjects: Grassland ecology , Global environmental change , Climatic changes
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/69382 , vital:77250
- Description: Grassy ecosystems are essential for human survival, providing key services including food production, water provisioning and moderating climate. Yet, grassy ecosystems remain undervalued due to misconceptions that they are remnants of degraded states of forest – a view that continues to influence climate change policies. This thesis explores the links between wild, free-roaming ungulate grazers and climate drivers, including carbon storage and surface albedo (i.e., reflectance of solar radiation), through their impacts on vegetation and soils. Using black wildebeest (Connochaetes gnou) as a model wild species, I compared their grazing patterns in an Afromontane grassland in the eastern Karoo, South Africa, to those of short-duration cattle grazing systems in similar nearby grasslands (Chapter 2). While short-duration grazing aims to mimic spatiotemporal wild ungulate grazing patterns to supposedly enhance ecosystem functioning and soil carbon stocks, I found that wildebeest had ~50% shorter grazing durations and much shorter rest intervals (1-5 days versus 60-365 days), revealing key differences in grazing patterns that may affect vegetation and climate feedbacks. Next, I examined spatial variations in soil organic carbon (SOC) stocks between grass growth forms that differ in grazing tolerance (Chapter 3). Red grass (Themeda triandra) tussock patches, sensitive to frequent grazing, had higher SOC to a soil depth of 20 cm (61.45 ± 1.59 Mg C·ha-1)than intensively grazed, prostrate-growing Cynodon dactylon grazing lawns (55.43 ± 3.40Mg C·ha-1), likely due to greater shading and soil moisture beneath tussocks which drives microbial decomposition. Seasonal albedo variations were then assessed across distinct grassland patch types among seasons to determine whether albedo varies seasonally at fine patch-scales between grass patches, between shrub and grass patches, and with grazing (Chapter 4). Albedo was lower during the growing season compared to dormancy, and was consistently lower in dwarf shrub (Pentzia incana) encroached patches compared to grass patches. No albedo differences between grazed and less-grazed tussock grass patches of the same species were found, although intensively grazed grazing lawns had consistently higher albedo than most patch types. Finally, I evaluated trade-offs between plant carbon, albedo, and their impacts on radiative forcing (i.e., atmospheric warming/cooling) resulting from patch type changes commonly found in grassy ecosystems (Chapter 5). The loss of perennial grass cover resulted in the highest net positive (warming) effect, mostly due to reduced root biomass. Additionally, shrub encroachment into all patches lowered albedo, but led to negative (cooling) effects from shrub encroachment into bare ground patches due to biomass gains. This thesis challenges current views of grassy landscapes and short-duration grazing systems, emphasizing the need to rethink climate change mitigation strategies to prioritize maintaining heterogeneity, while enhancing carbon sequestration and albedo in grassy ecosystems. , Thesis (PhD) -- Faculty of Science, School of Environmental Sciences, 2024
- Full Text:
- Date Issued: 2024-12
Causative factors for poor contractor performance in schools infrastructure projects
- Authors: Baba, Vuyiseka
- Date: 2024-12
- Subjects: Project management , Project management -- Evaluation , School facilities -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68703 , vital:77083
- Description: The public sector infrastructure departments in South Africa rely on construction companies as the major stakeholders in the implementation and maintenance of infrastructure facilities including schools. The Limpopo Province is faced with a serious challenge of underperforming contractors. This in turn affects the Provincial Government’s effective delivery of the much-needed quality infrastructure and facilities. A significant number of schools in the province are faced with infrastructure challenges including sanitation facilities, deteriorating school buildings, storm damage, inadequate infrastructure for special schools, water provision, and general maintenance. This study sought to understand the challenges faced by contractors and further explored whether the effective application of project management methodologies can have a positive impact on improving the current underperformance. Due to the nature of the study, a qualitative research method was employed to collect data. An interpretivist paradigm was adopted as the research philosophy, as it allowed for a flexible and in-depth investigation approach. The study utilized an exploratory research design. The targeted population for the study was carefully selected to obtain relevant and reliable data, and a purposive sampling technique was chosen. Semi-structured interviews were conducted as the primary data collection method, enabling the collection of first-hand information. To ensure accuracy and prevent loss of information, the research process involved recording and transcribing the interviews, using an inductive analysis approach. Eighteen out of the twenty targeted participants were successfully interviewed, resulting in a response rate of 90%. The findings of the study revealed that poor planning, inadequate financial management, inexperienced staff, interference from stakeholders, and a misunderstanding of project scope were among the many factors contributing to poor contractor performance. Furthermore, contractors, particularly Small and Medium Enterprises (SMEs), faced serious challenges during project implementation, including a lack of proper training, budget constraints, and delayed payments from clients. Based on the study's findings, it is recommended that contractors invest in planning and cost management software, including project management methodologies such as Agile, Waterfall, and MS Project. Further, contractors are encouraged to employ adequately skilled and qualified site personnel. Clients should also consider supporting underperforming contractors by pairing them with proven-performing ones to encourage mentorship and other forms of capacity building. , Thesis (MSc) -- Faculty of Engineering, the Built Environment, and Technology, School of Building and Human Settlements Management, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Baba, Vuyiseka
- Date: 2024-12
- Subjects: Project management , Project management -- Evaluation , School facilities -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68703 , vital:77083
- Description: The public sector infrastructure departments in South Africa rely on construction companies as the major stakeholders in the implementation and maintenance of infrastructure facilities including schools. The Limpopo Province is faced with a serious challenge of underperforming contractors. This in turn affects the Provincial Government’s effective delivery of the much-needed quality infrastructure and facilities. A significant number of schools in the province are faced with infrastructure challenges including sanitation facilities, deteriorating school buildings, storm damage, inadequate infrastructure for special schools, water provision, and general maintenance. This study sought to understand the challenges faced by contractors and further explored whether the effective application of project management methodologies can have a positive impact on improving the current underperformance. Due to the nature of the study, a qualitative research method was employed to collect data. An interpretivist paradigm was adopted as the research philosophy, as it allowed for a flexible and in-depth investigation approach. The study utilized an exploratory research design. The targeted population for the study was carefully selected to obtain relevant and reliable data, and a purposive sampling technique was chosen. Semi-structured interviews were conducted as the primary data collection method, enabling the collection of first-hand information. To ensure accuracy and prevent loss of information, the research process involved recording and transcribing the interviews, using an inductive analysis approach. Eighteen out of the twenty targeted participants were successfully interviewed, resulting in a response rate of 90%. The findings of the study revealed that poor planning, inadequate financial management, inexperienced staff, interference from stakeholders, and a misunderstanding of project scope were among the many factors contributing to poor contractor performance. Furthermore, contractors, particularly Small and Medium Enterprises (SMEs), faced serious challenges during project implementation, including a lack of proper training, budget constraints, and delayed payments from clients. Based on the study's findings, it is recommended that contractors invest in planning and cost management software, including project management methodologies such as Agile, Waterfall, and MS Project. Further, contractors are encouraged to employ adequately skilled and qualified site personnel. Clients should also consider supporting underperforming contractors by pairing them with proven-performing ones to encourage mentorship and other forms of capacity building. , Thesis (MSc) -- Faculty of Engineering, the Built Environment, and Technology, School of Building and Human Settlements Management, 2024
- Full Text:
- Date Issued: 2024-12
Challenges and prospects of the billing system in a selected municipality – a dialectic examination
- Authors: Mda, Lindokuhle Primrose
- Date: 2024-12
- Subjects: Municipal finance -- South Africa -- Nelson Mandela Bay Municipality -- Accounting -- Data processing , Municipal services -- South Africa -- Nelson Mandela Bay Municipality , Local government -- Finance
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70089 , vital:78293
- Description: The purpose of this study was to investigate the challenges and prospects of the billing system in a municipality in South Africa. Municipalities play an important role in providing services to business owners and residents. Of late the media has been awash by the incorrect billing that is caused by the faulty billing system in most South African Municipalities. Although there is a lot of literature re on the billing systems, there is a dearth of studies when it comes to south African context particularly at Buffalo City Metropolitan Municipality (BCMM). Therefore, it is important to explore the challenges and prospect that comes with the billing system in the chosen municipality to fill in the literature gap. A qualitative approach was employed whereby 12 participants, who were sampled using the non-probability, purposive technique were interviewed. The study analysed data using the thematic analysis technique. Semi-structured questions were asked during interviews as a data collection method. The participants provided a comprehensive coverage (CC) of the new billing prospects. The sub-themes namely incorrect and inaccurate billing, estimated bills, lack of incentives to pursue collection, negligence, corruption, enhanced revenue collection, enhancing record management, gathering relevant information from residents and the use of mobile payment solutions was partially covered (PC). The rest of the sub-themes were comprehensively covered. The results reveal that, on average all the themes were covered in the interview implying that the participants understood the challenges faced by the billing system in BCMM, the prospects that are associated by the introduction of new billing systems, the root causes of challenges within the billing system, strategies needed to be implemented and the use of new technology and innovation. All participants acknowledge the fact that the billing system used by the municipality has a lot of challenges and there is a requirement to either upgrade it or discard it in total and replace it with technological advanced smart meters to enable accurate and correct billing. The effects of the incorrect billing were felt by both the municipal management and residents The study recommends that municipalities in South Africa, particularly BCMM should integrate their billing system with new technology to optimise their service delivery system and enhance their revenue collection. Suggested billing software to be used in municipalities include SAP, SKYBILL Utility Billing and full ERP billing, among others. This software offer a range of benefits such as easy to monitor records, revenue collection enhancements and efficiency. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Mda, Lindokuhle Primrose
- Date: 2024-12
- Subjects: Municipal finance -- South Africa -- Nelson Mandela Bay Municipality -- Accounting -- Data processing , Municipal services -- South Africa -- Nelson Mandela Bay Municipality , Local government -- Finance
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70089 , vital:78293
- Description: The purpose of this study was to investigate the challenges and prospects of the billing system in a municipality in South Africa. Municipalities play an important role in providing services to business owners and residents. Of late the media has been awash by the incorrect billing that is caused by the faulty billing system in most South African Municipalities. Although there is a lot of literature re on the billing systems, there is a dearth of studies when it comes to south African context particularly at Buffalo City Metropolitan Municipality (BCMM). Therefore, it is important to explore the challenges and prospect that comes with the billing system in the chosen municipality to fill in the literature gap. A qualitative approach was employed whereby 12 participants, who were sampled using the non-probability, purposive technique were interviewed. The study analysed data using the thematic analysis technique. Semi-structured questions were asked during interviews as a data collection method. The participants provided a comprehensive coverage (CC) of the new billing prospects. The sub-themes namely incorrect and inaccurate billing, estimated bills, lack of incentives to pursue collection, negligence, corruption, enhanced revenue collection, enhancing record management, gathering relevant information from residents and the use of mobile payment solutions was partially covered (PC). The rest of the sub-themes were comprehensively covered. The results reveal that, on average all the themes were covered in the interview implying that the participants understood the challenges faced by the billing system in BCMM, the prospects that are associated by the introduction of new billing systems, the root causes of challenges within the billing system, strategies needed to be implemented and the use of new technology and innovation. All participants acknowledge the fact that the billing system used by the municipality has a lot of challenges and there is a requirement to either upgrade it or discard it in total and replace it with technological advanced smart meters to enable accurate and correct billing. The effects of the incorrect billing were felt by both the municipal management and residents The study recommends that municipalities in South Africa, particularly BCMM should integrate their billing system with new technology to optimise their service delivery system and enhance their revenue collection. Suggested billing software to be used in municipalities include SAP, SKYBILL Utility Billing and full ERP billing, among others. This software offer a range of benefits such as easy to monitor records, revenue collection enhancements and efficiency. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
Characterization of the molecular mechanism(s) of cannabinoid-induced paraptosis in breast cancer cells
- Authors: de la Harpe, Amy
- Date: 2024-12
- Subjects: Cannabinoids , Cannabinoids -- Therapeutic use , Cancer cells
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/68818 , vital:77120
- Description: Natural products have been extensively studied for their anticancer potential, and several widely used anticancer drugs have natural origins. Many studies have demonstrated that natural compounds can induce paraptosis in various tumour cell lines. Paraptosis is a caspase-independent cell death mechanism characterised by cytoplasmic vacuolation arising from the endoplasmic reticulum (ER) and the mitochondria. The molecular mechanism of paraptosis is unclear; however, the literature indicates that dysregulation of calcium signalling plays an important role in paraptosis induction, particularly calcium-mediated signalling between the ER and mitochondria. This study aimed to identify and characterise the mechanism of cell death induced by a phytocannabinoid ratio which induced significant cytoplasmic vacuolation in the MCF7 breast cancer cell line. Several techniques were employed to address the aim of the study. The crystal violet assay was used to detect changes in viability. Several pathway inhibitors, as well as fluorescent staining and analysis using high-content screening (HCS), were used to measure the induction of various cell death mechanisms. Morphological changes were investigated using light and transmission electron microscopy. The phytocannabinoid ratio induced significant cell death and cytoplasmic vacuolation in MCF7 cells; however, the same trend was not observed in the MCF10A non-tumourigenic breast cell line. No cell cycle arrest, apoptosis, necrosis, autophagy, or ferroptosis induction was detected in MCF7 cells, suggesting that an alternative mechanism of cell death was induced. Vacuolation and cell death induced by the phytocannabinoid ratio were inhibited by cycloheximide, suggesting a dependence on protein synthesis, which is characteristic of paraptosis induction. The mechanism of paraptosis induction by the phytocannabinoid ratio was investigated, and it was found that treatment 1) induced ER dilation and mitochondrial swelling; 2) induced significant ER stress, mitochondrial calcium overload, and mitochondrial dysfunction which appeared to be mediated by the voltage-dependent anion channel (VDAC); and 3) significantly impaired all mitochondrial metabolic pathways. Overall, the data demonstrated that paraptosis induced by the cannabinoid ratio is mediated by calcium flux from the ER to the mitochondria. This highlighted a novel mechanism of phytocannabinoid-induced cell death and emphasised the anti-cancer potential of the use of phytocannabinoid ratios as opposed to individual phytocannabinoids, expanding their potential for use as anticancer agents. , Thesis (PhD) -- Faculty of Science, School of Biomolecular & Chemical Sciences, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: de la Harpe, Amy
- Date: 2024-12
- Subjects: Cannabinoids , Cannabinoids -- Therapeutic use , Cancer cells
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/68818 , vital:77120
- Description: Natural products have been extensively studied for their anticancer potential, and several widely used anticancer drugs have natural origins. Many studies have demonstrated that natural compounds can induce paraptosis in various tumour cell lines. Paraptosis is a caspase-independent cell death mechanism characterised by cytoplasmic vacuolation arising from the endoplasmic reticulum (ER) and the mitochondria. The molecular mechanism of paraptosis is unclear; however, the literature indicates that dysregulation of calcium signalling plays an important role in paraptosis induction, particularly calcium-mediated signalling between the ER and mitochondria. This study aimed to identify and characterise the mechanism of cell death induced by a phytocannabinoid ratio which induced significant cytoplasmic vacuolation in the MCF7 breast cancer cell line. Several techniques were employed to address the aim of the study. The crystal violet assay was used to detect changes in viability. Several pathway inhibitors, as well as fluorescent staining and analysis using high-content screening (HCS), were used to measure the induction of various cell death mechanisms. Morphological changes were investigated using light and transmission electron microscopy. The phytocannabinoid ratio induced significant cell death and cytoplasmic vacuolation in MCF7 cells; however, the same trend was not observed in the MCF10A non-tumourigenic breast cell line. No cell cycle arrest, apoptosis, necrosis, autophagy, or ferroptosis induction was detected in MCF7 cells, suggesting that an alternative mechanism of cell death was induced. Vacuolation and cell death induced by the phytocannabinoid ratio were inhibited by cycloheximide, suggesting a dependence on protein synthesis, which is characteristic of paraptosis induction. The mechanism of paraptosis induction by the phytocannabinoid ratio was investigated, and it was found that treatment 1) induced ER dilation and mitochondrial swelling; 2) induced significant ER stress, mitochondrial calcium overload, and mitochondrial dysfunction which appeared to be mediated by the voltage-dependent anion channel (VDAC); and 3) significantly impaired all mitochondrial metabolic pathways. Overall, the data demonstrated that paraptosis induced by the cannabinoid ratio is mediated by calcium flux from the ER to the mitochondria. This highlighted a novel mechanism of phytocannabinoid-induced cell death and emphasised the anti-cancer potential of the use of phytocannabinoid ratios as opposed to individual phytocannabinoids, expanding their potential for use as anticancer agents. , Thesis (PhD) -- Faculty of Science, School of Biomolecular & Chemical Sciences, 2024
- Full Text:
- Date Issued: 2024-12
Chicory production for sustainable economic development of Alexandria in Ndlambe Local Municipality
- Authors: Mampana, Qawekazi
- Date: 2024-12
- Subjects: Economic development -- South Africa -- Eastern Cape , Sustainable development -- South Africa -- Eastern Cape , Chicory -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70133 , vital:78303
- Description: The apartheid regime that governed South Africa prior to the democratic transition pursued and implemented ethnically motivated policies and legislation that promoted racial segregation. As a result, the democratic government inherited a country plagued by unemployment, poverty, and inequality challenges. In response, the democratic government identified cooperatives as one mechanism to address these structural challenges and undo the legacy of apartheid, leading to an increase in the number of registered cooperatives in the country. Studies have shown that cooperatives could help propel community development in South Africa, especially in rural communities. It is argued that cooperatives have the potential to increase public participation and thus forge unity and togetherness among communities. Scholars indicate that public participation can improve community development and access to service delivery and enhance political influence and other resources that, in turn, will sustain human capital. Furthermore, studies have also shown that assisting and mobilising poor communities to work together is crucial for community development. However, despite cooperatives’ imperative role in community development, most struggle to sustain themselves and eventually become inactive, especially in rural communities. The study was conducted in Alexandria, a small rural town within the Ndlambe Local Municipality (NLM) in the Eastern Cape Province. The study’s main aim was to interrogate the current state of chicory production in Alexandria from the perspectives of community cooperatives operating in the chicory sector. The study also sought to interrogate the phenomenon under study from the perspectives of Chicory South Africa (CSA) and government officials from the Eastern Cape Provincial Government. CSA provides administrative and technical support in the sector, and the provincial government provides financial and other support instruments to the community cooperatives operating in the sector. The study adopted a qualitative research approach and used purposive sampling to identify and select participants. The study included 14 participants that were purposively identified and selected by the researcher based on their capabilities to illuminate the phenomena under study. The data was collected through semi-structured interviews with the participants and corroborated with a literature review in the context of cooperatives in South Africa. Considering the qualitative nature of the study, the researcher deemed it prudent to utilise the constructivism research paradigm. The constructivism paradigm is premised on the notion that reality is socially constructed; thus, there are multiple realities that are shaped by people’s unique experiences of the social world in which they live and work. The study used thematic analysis to analyse the data. The findings reveal that the significant issues cooperatives face include inter alia lack of access to capital, insufficient government intervention, climate change, and lack of capacity among members. The findings further reveal that local government must assist cooperatives by providing them with capital and technical support. The study recommends that all spheres of government must engage in work and support initiatives that aim to create a sustainable and conducive environment for community development. In this regard, it is recommended that the government take a leading role in supporting cooperatives and ensure their activities and objectives align with government efforts towards sustainable community development, which will create synergy between the government and cooperatives. , Thesis (MA) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Mampana, Qawekazi
- Date: 2024-12
- Subjects: Economic development -- South Africa -- Eastern Cape , Sustainable development -- South Africa -- Eastern Cape , Chicory -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70133 , vital:78303
- Description: The apartheid regime that governed South Africa prior to the democratic transition pursued and implemented ethnically motivated policies and legislation that promoted racial segregation. As a result, the democratic government inherited a country plagued by unemployment, poverty, and inequality challenges. In response, the democratic government identified cooperatives as one mechanism to address these structural challenges and undo the legacy of apartheid, leading to an increase in the number of registered cooperatives in the country. Studies have shown that cooperatives could help propel community development in South Africa, especially in rural communities. It is argued that cooperatives have the potential to increase public participation and thus forge unity and togetherness among communities. Scholars indicate that public participation can improve community development and access to service delivery and enhance political influence and other resources that, in turn, will sustain human capital. Furthermore, studies have also shown that assisting and mobilising poor communities to work together is crucial for community development. However, despite cooperatives’ imperative role in community development, most struggle to sustain themselves and eventually become inactive, especially in rural communities. The study was conducted in Alexandria, a small rural town within the Ndlambe Local Municipality (NLM) in the Eastern Cape Province. The study’s main aim was to interrogate the current state of chicory production in Alexandria from the perspectives of community cooperatives operating in the chicory sector. The study also sought to interrogate the phenomenon under study from the perspectives of Chicory South Africa (CSA) and government officials from the Eastern Cape Provincial Government. CSA provides administrative and technical support in the sector, and the provincial government provides financial and other support instruments to the community cooperatives operating in the sector. The study adopted a qualitative research approach and used purposive sampling to identify and select participants. The study included 14 participants that were purposively identified and selected by the researcher based on their capabilities to illuminate the phenomena under study. The data was collected through semi-structured interviews with the participants and corroborated with a literature review in the context of cooperatives in South Africa. Considering the qualitative nature of the study, the researcher deemed it prudent to utilise the constructivism research paradigm. The constructivism paradigm is premised on the notion that reality is socially constructed; thus, there are multiple realities that are shaped by people’s unique experiences of the social world in which they live and work. The study used thematic analysis to analyse the data. The findings reveal that the significant issues cooperatives face include inter alia lack of access to capital, insufficient government intervention, climate change, and lack of capacity among members. The findings further reveal that local government must assist cooperatives by providing them with capital and technical support. The study recommends that all spheres of government must engage in work and support initiatives that aim to create a sustainable and conducive environment for community development. In this regard, it is recommended that the government take a leading role in supporting cooperatives and ensure their activities and objectives align with government efforts towards sustainable community development, which will create synergy between the government and cooperatives. , Thesis (MA) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2024
- Full Text:
- Date Issued: 2024-12
Co-generated learnings from hopes-an NRF grant funded university engagement project
- Authors: Quvile, Xola Bulumko
- Date: 2024-12
- Subjects: National Research Foundation (South Africa) , Research grants -- South Africa , Education, Higher -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68366 , vital:76990
- Description: The study had sought to understand the systemic and individual factors that facilitated or inhibited the NRF grant-funded HOPES Project. HOPES collaborated with the Centre for the Community School in the Faculty of Education, and various communities of practice (COPs) in existing school communities in the Eastern Cape Province of South Africa. The project applied a critical participatory action research work to develop a framework for school improvement and in the process contribute to making schools beacons of hope. This research provides insights into how an NRF community engagement grant project team (HOPES) navigated external and internal factors such as COVID-19, rules regulating the grant, and multiple realities of the stakeholders at play. The study was qualitative and used the critical participatory action research design. The study purposively and conveniently sampled seven HOPES Project team members to collect data via focus groups and individual interviews and collected secondary data from NRF HOPES annual project reports. The study findings improved the participants' understanding of their journey, and the co-generated knowledge shed light on how NFR and community engagement grant funders could promote enabling conditions towards achieving individual scholars and collective project outcomes. The study findings provide learnings for the Faculty of Education and the Nelson Mandela University on how extrinsic and intrinsic enablers and barriers can be addressed to optimise a project of this nature. , Thesis (MEd) -- Faculty of Education, School of Postgraduate Education, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Quvile, Xola Bulumko
- Date: 2024-12
- Subjects: National Research Foundation (South Africa) , Research grants -- South Africa , Education, Higher -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68366 , vital:76990
- Description: The study had sought to understand the systemic and individual factors that facilitated or inhibited the NRF grant-funded HOPES Project. HOPES collaborated with the Centre for the Community School in the Faculty of Education, and various communities of practice (COPs) in existing school communities in the Eastern Cape Province of South Africa. The project applied a critical participatory action research work to develop a framework for school improvement and in the process contribute to making schools beacons of hope. This research provides insights into how an NRF community engagement grant project team (HOPES) navigated external and internal factors such as COVID-19, rules regulating the grant, and multiple realities of the stakeholders at play. The study was qualitative and used the critical participatory action research design. The study purposively and conveniently sampled seven HOPES Project team members to collect data via focus groups and individual interviews and collected secondary data from NRF HOPES annual project reports. The study findings improved the participants' understanding of their journey, and the co-generated knowledge shed light on how NFR and community engagement grant funders could promote enabling conditions towards achieving individual scholars and collective project outcomes. The study findings provide learnings for the Faculty of Education and the Nelson Mandela University on how extrinsic and intrinsic enablers and barriers can be addressed to optimise a project of this nature. , Thesis (MEd) -- Faculty of Education, School of Postgraduate Education, 2024
- Full Text:
- Date Issued: 2024-12
Collaborative conservation governance in multifunctional landscapes: a contextual analysis of two South African biosphere reserves in the Boland
- Authors: Klaver, Michael
- Date: 2024-12
- Subjects: Unesco -- Programme on Man and the Biosphere , Nature conservation -- South Africa , Biosphere
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68924 , vital:77164
- Description: The Man and the Biosphere Programme (MAB) has been earmarked as one of the most promising ways of tackling the grand challenges of our time and achieving the Sustainable Development Goals. Furthermore, it may have the potential to make positive contributions to one of the most troubling conservation challenges of our time – winning spaces for large carnivores in human-dominated landscapes. This study aims to assess the interpretation and implementation of MAB in two South African Biosphere Reserves (BRs) and explore how BRs as landscape level collaborative initiatives can support Cape leopard conservation in the Boland region of the Western Cape, South Africa. This study is informed by two objectives. First, to understand how the chosen governance strategy and structure of two South African BRs have helped to achieve a context appropriate interpretation and actioning of MAB in the landscape. Second, to understand how landscape-level collaborative conservation initiatives support leopard conservation across a multifunctional landscape. This study takes on a mixed methods approach in which qualitative data takes priority and quantitative data is used for support in an embedded multiple-case study design. The sampling techniques used include purposive sampling of strategically targeted participants, i.e. those governing BRs and those leading the collaborative initiative and snowballing thereon. Data collection included a combination of semi-structure interviews (n=20) (the principal collection method), a review of archival, policy and other documents (n=15), and supported by a mixed methods survey questionnaire (n=5). Data were analysed through thematic and content analysis. Findings suggest that organisations working at a landscape-level utilise forms of adaptive co-management and/or governance as a means to being both adaptive and collaborative. Important themes which emerge include cross-sectoral approaches, networks, leadership and trust for building partnerships, shared visions and ‘filling gaps’ left by, or collaborating with the state to fulfil mutually beneficial objectives. This research provides empirical studies on MAB, important for sharing knowledge across the World Network of BRs, meeting the need for further research on collaborative initiatives in social-ecological systems and conservation programmes for large free-roaming carnivores in multifunctional landscapes. , Thesis (MSc) -- Faculty of Science, School of Natural Resource Science & Management, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Klaver, Michael
- Date: 2024-12
- Subjects: Unesco -- Programme on Man and the Biosphere , Nature conservation -- South Africa , Biosphere
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68924 , vital:77164
- Description: The Man and the Biosphere Programme (MAB) has been earmarked as one of the most promising ways of tackling the grand challenges of our time and achieving the Sustainable Development Goals. Furthermore, it may have the potential to make positive contributions to one of the most troubling conservation challenges of our time – winning spaces for large carnivores in human-dominated landscapes. This study aims to assess the interpretation and implementation of MAB in two South African Biosphere Reserves (BRs) and explore how BRs as landscape level collaborative initiatives can support Cape leopard conservation in the Boland region of the Western Cape, South Africa. This study is informed by two objectives. First, to understand how the chosen governance strategy and structure of two South African BRs have helped to achieve a context appropriate interpretation and actioning of MAB in the landscape. Second, to understand how landscape-level collaborative conservation initiatives support leopard conservation across a multifunctional landscape. This study takes on a mixed methods approach in which qualitative data takes priority and quantitative data is used for support in an embedded multiple-case study design. The sampling techniques used include purposive sampling of strategically targeted participants, i.e. those governing BRs and those leading the collaborative initiative and snowballing thereon. Data collection included a combination of semi-structure interviews (n=20) (the principal collection method), a review of archival, policy and other documents (n=15), and supported by a mixed methods survey questionnaire (n=5). Data were analysed through thematic and content analysis. Findings suggest that organisations working at a landscape-level utilise forms of adaptive co-management and/or governance as a means to being both adaptive and collaborative. Important themes which emerge include cross-sectoral approaches, networks, leadership and trust for building partnerships, shared visions and ‘filling gaps’ left by, or collaborating with the state to fulfil mutually beneficial objectives. This research provides empirical studies on MAB, important for sharing knowledge across the World Network of BRs, meeting the need for further research on collaborative initiatives in social-ecological systems and conservation programmes for large free-roaming carnivores in multifunctional landscapes. , Thesis (MSc) -- Faculty of Science, School of Natural Resource Science & Management, 2024
- Full Text:
- Date Issued: 2024-12
Collaborative conservation governance in multifunctional landscapes: a contextual analysis of two South African Biosphere Reserves in the Boland
- Authors: Klaver, Michael
- Date: 2024-12
- Subjects: Unesco. -- Programme on Man and the Biosphere , Nature conservation -- South Africa , Social ecology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68918 , vital:77165
- Description: The Man and the Biosphere Programme (MAB) has been earmarked as one of the most promising ways of tackling the grand challenges of our time and achieving the Sustainable Development Goals. Furthermore, it may have the potential to make positive contributions to one of the most troubling conservation challenges of our time – winning spaces for large carnivores in human-dominated landscapes. This study aims to assess the interpretation and implementation of MAB in two South African Biosphere Reserves (BRs) and explore how BRs as landscape level collaborative initiatives can support Cape leopard conservation in the Boland region of the Western Cape, South Africa. This study is informed by two objectives. First, to understand how the chosen governance strategy and structure of two South African BRs have helped to achieve a context appropriate interpretation and actioning of MAB in the landscape. Second, to understand how landscape-level collaborative conservation initiatives support leopard conservation across a multifunctional landscape. This study takes on a mixed methods approach in which qualitative data takes priority and quantitative data is used for support in an embedded multiple-case study design. The sampling techniques used include purposive sampling of strategically targeted participants, i.e. those governing BRs and those leading the collaborative initiative and snowballing thereon. Data collection included a combination of semi-structure interviews (n=20) (the principal collection method), a review of archival, policy and other documents (n=15), and supported by a mixed methods survey questionnaire (n=5). Data were analysed through thematic and content analysis. Findings suggest that organisations working at a landscape-level utilise forms of adaptive co-management and/or governance as a means to being both adaptive and collaborative. Important themes which emerge include cross-sectoral approaches, networks, leadership and trust for building partnerships, shared visions and ‘filling gaps’ left by, or collaborating with the state to fulfil mutually beneficial objectives. This research provides empirical studies on MAB, important for sharing knowledge across the World Network of BRs, meeting the need for further research on collaborative initiatives in social-ecological systems and conservation programmes for large free-roaming carnivores in multifunctional landscapes. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Klaver, Michael
- Date: 2024-12
- Subjects: Unesco. -- Programme on Man and the Biosphere , Nature conservation -- South Africa , Social ecology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68918 , vital:77165
- Description: The Man and the Biosphere Programme (MAB) has been earmarked as one of the most promising ways of tackling the grand challenges of our time and achieving the Sustainable Development Goals. Furthermore, it may have the potential to make positive contributions to one of the most troubling conservation challenges of our time – winning spaces for large carnivores in human-dominated landscapes. This study aims to assess the interpretation and implementation of MAB in two South African Biosphere Reserves (BRs) and explore how BRs as landscape level collaborative initiatives can support Cape leopard conservation in the Boland region of the Western Cape, South Africa. This study is informed by two objectives. First, to understand how the chosen governance strategy and structure of two South African BRs have helped to achieve a context appropriate interpretation and actioning of MAB in the landscape. Second, to understand how landscape-level collaborative conservation initiatives support leopard conservation across a multifunctional landscape. This study takes on a mixed methods approach in which qualitative data takes priority and quantitative data is used for support in an embedded multiple-case study design. The sampling techniques used include purposive sampling of strategically targeted participants, i.e. those governing BRs and those leading the collaborative initiative and snowballing thereon. Data collection included a combination of semi-structure interviews (n=20) (the principal collection method), a review of archival, policy and other documents (n=15), and supported by a mixed methods survey questionnaire (n=5). Data were analysed through thematic and content analysis. Findings suggest that organisations working at a landscape-level utilise forms of adaptive co-management and/or governance as a means to being both adaptive and collaborative. Important themes which emerge include cross-sectoral approaches, networks, leadership and trust for building partnerships, shared visions and ‘filling gaps’ left by, or collaborating with the state to fulfil mutually beneficial objectives. This research provides empirical studies on MAB, important for sharing knowledge across the World Network of BRs, meeting the need for further research on collaborative initiatives in social-ecological systems and conservation programmes for large free-roaming carnivores in multifunctional landscapes. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2024
- Full Text:
- Date Issued: 2024-12
Communicating positive representations of wheelchair users’ disability identities through illustration and participatory design
- Authors: du Plessis, Amberleigh
- Date: 2024-12
- Subjects: People with disabilities , Group identity , Visual communication
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70297 , vital:78337
- Description: The study highlights the misrepresentation of people with disabilities in the media, and how it can lead to social exclusion of people with disabilities and misunderstanding of the disability identity. The research question involves disability representation, wheelchair-disabled identity, illustration and participatory design. The study focuses specifically on wheelchair disability and uses a participatory design approach, which allows for wheelchair users collectively to be part of the research. The three different models of disability, namely the medical model, the social model and the cultural model. The South African definition of disability is explored, and images and photographic examples of past representations of disability are examined to identify stereotypes, such as the freak, the medicalised disabled body and the pitiful victim. Positive illustrations, paintings and posters of people living with disabilities are analysed, focusing on physical disability and representation, which reveals that illustration can instil good staring habits from non-disabled viewers, to create a more inclusive society. A qualitative research approach is employed to gain a better understanding of a specific phenomenon. The specific phenomenon was the representation of wheelchair disability identities, and to untangle this, three research approaches were used, namely autoethnography, case studies and participatory design. A total of 10 wheelchair-disabled persons, from Cheshire Home Summerstrand in Gqeberha participated in the study. It was found that by involving participants in the practical development process, more positive illustrations of disability representation can be produced, allowing for clearer communication of the disability identity. The responses to the interview questions confirmed that people with disabilities believe that non-disabled people have misconceptions about the disability identity. The research thus aims to challenge these misconceptions and motivate more positive interpretations and understanding of the disability identity through visual communication. , Thesis (MVA) -- Faculty of Humanities, School of Visual and Performing Arts, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: du Plessis, Amberleigh
- Date: 2024-12
- Subjects: People with disabilities , Group identity , Visual communication
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70297 , vital:78337
- Description: The study highlights the misrepresentation of people with disabilities in the media, and how it can lead to social exclusion of people with disabilities and misunderstanding of the disability identity. The research question involves disability representation, wheelchair-disabled identity, illustration and participatory design. The study focuses specifically on wheelchair disability and uses a participatory design approach, which allows for wheelchair users collectively to be part of the research. The three different models of disability, namely the medical model, the social model and the cultural model. The South African definition of disability is explored, and images and photographic examples of past representations of disability are examined to identify stereotypes, such as the freak, the medicalised disabled body and the pitiful victim. Positive illustrations, paintings and posters of people living with disabilities are analysed, focusing on physical disability and representation, which reveals that illustration can instil good staring habits from non-disabled viewers, to create a more inclusive society. A qualitative research approach is employed to gain a better understanding of a specific phenomenon. The specific phenomenon was the representation of wheelchair disability identities, and to untangle this, three research approaches were used, namely autoethnography, case studies and participatory design. A total of 10 wheelchair-disabled persons, from Cheshire Home Summerstrand in Gqeberha participated in the study. It was found that by involving participants in the practical development process, more positive illustrations of disability representation can be produced, allowing for clearer communication of the disability identity. The responses to the interview questions confirmed that people with disabilities believe that non-disabled people have misconceptions about the disability identity. The research thus aims to challenge these misconceptions and motivate more positive interpretations and understanding of the disability identity through visual communication. , Thesis (MVA) -- Faculty of Humanities, School of Visual and Performing Arts, 2024
- Full Text:
- Date Issued: 2024-12
Comparative study of the effect of iloprost on neuroinflammatory changes in c8-b4 microglial cells and murine model of trypanosomiasis
- Authors: Jacobs, Ashleigh
- Date: 2024-12
- Subjects: Neuroimmunology , DNA -- Methylation , Nervous system -- Degeneration
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68895 , vital:77160
- Description: Neurodegenerative conditions significantly impact well-being and quality of life in individuals with major symptoms including mood disorders, cognitive decline, and psychiatric disturbances, often resulting from neuroinflammation triggered by immune responses to bacterial or parasitic infections such as gram-negative bacteria or Human African Trypanosomiasis. Microglia play a crucial role in both neurotoxicity and cellular processes involved in restoring the neural health. Exploring the therapeutic potential of prostacyclin and its analogues in regulating microglia responses to inflammatory insult and treating Trypanosoma brucei (T.b) infection remains an unexplored area. The aim of this study was to assess the potential neuroprotective effects of Iloprost through comparative analysis of neuroinflammatory responses in both microglial cells exposed to lipopolysaccharide (LPS) and mouse brains infected with T.b brucei. In phase I of this study both resting and LPS treated C8-B4 microglial cells were exposed to varying concentrations of Iloprost. The effects of Iloprost on LPS-induced inflammation were analysed using immunofluorescence to detect microglial activation and differentiate between pro and anti-inflammatory phenotypes. Furthermore, pro and anti-inflammatory cytokine secretion was determined using an ELISA, in addition gene expression analysis was carried out using quantitative polymerase chain reaction (qPCR). Also, DNA methylation status of C8-B4 cells exposed to LPS challenge alone or in combination with various concentrations of Iloprost were determined using bisulfite sequencing technique followed by qPCR. In phase II of the study, a total of twenty-four Albino Swiss male mice (8-10 weeks old) were divided into four treatment groups with 6 mice in each group. All treatment groups except the non-infected control were inoculated with the T.b brucei parasite. One group received a single intraperitoneal injection of Diminazene aceturate (4 mg kg-1)while the remaining group received repeated intraperitoneal injections of Iloprost (200 μg kg-1). On day ten of the study, mouse brains were removed on ice using forceps. The hippocampal tissues were dissected out and processed for quantification of gene expression changes in pro and anti-inflammatory cytokines. Overall, the findings of this study indicate that LPS-induced pro-inflammatory cytokine, TNF-α and IL-1β, secretion and gene expression is down-regulated in C8-B4 microglial cells treated with Iloprost. Furthermore, there was a significant up-regulation in the expression of anti-inflammatory genes, particularly ARG-1, CD206, BDNF and CREB in response to Iloprost treatment following LPS-induced inflammation. This study is also the first to confirm M2 microglial polarization with Iloprost treatment in both resting and LPS treated cells. However, hypermethylation at CREB and BDNF promoter regions was observed 24 hours after Iloprost treatment. Additionally, Iloprost reversed hypomethylation at the BDNF promoter region that had been induced by LPS treatment. The rodent model also indicated a downregulation in the pro-inflammatory cytokine, IL-1β, expression and upregulation of BDNF transcription in T.b brucei infected mice treated with repeated doses of Iloprost. In conclusion, determining the immunomodulatory roles of Iloprost in both in vitro and in vivo models of neuroinflammation could assist in the development of alternative therapy for neurodegenerative disease. , Thesis (MSc) -- Faculty of Science, School of Biomolecular & Chemical Sciences, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Jacobs, Ashleigh
- Date: 2024-12
- Subjects: Neuroimmunology , DNA -- Methylation , Nervous system -- Degeneration
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/68895 , vital:77160
- Description: Neurodegenerative conditions significantly impact well-being and quality of life in individuals with major symptoms including mood disorders, cognitive decline, and psychiatric disturbances, often resulting from neuroinflammation triggered by immune responses to bacterial or parasitic infections such as gram-negative bacteria or Human African Trypanosomiasis. Microglia play a crucial role in both neurotoxicity and cellular processes involved in restoring the neural health. Exploring the therapeutic potential of prostacyclin and its analogues in regulating microglia responses to inflammatory insult and treating Trypanosoma brucei (T.b) infection remains an unexplored area. The aim of this study was to assess the potential neuroprotective effects of Iloprost through comparative analysis of neuroinflammatory responses in both microglial cells exposed to lipopolysaccharide (LPS) and mouse brains infected with T.b brucei. In phase I of this study both resting and LPS treated C8-B4 microglial cells were exposed to varying concentrations of Iloprost. The effects of Iloprost on LPS-induced inflammation were analysed using immunofluorescence to detect microglial activation and differentiate between pro and anti-inflammatory phenotypes. Furthermore, pro and anti-inflammatory cytokine secretion was determined using an ELISA, in addition gene expression analysis was carried out using quantitative polymerase chain reaction (qPCR). Also, DNA methylation status of C8-B4 cells exposed to LPS challenge alone or in combination with various concentrations of Iloprost were determined using bisulfite sequencing technique followed by qPCR. In phase II of the study, a total of twenty-four Albino Swiss male mice (8-10 weeks old) were divided into four treatment groups with 6 mice in each group. All treatment groups except the non-infected control were inoculated with the T.b brucei parasite. One group received a single intraperitoneal injection of Diminazene aceturate (4 mg kg-1)while the remaining group received repeated intraperitoneal injections of Iloprost (200 μg kg-1). On day ten of the study, mouse brains were removed on ice using forceps. The hippocampal tissues were dissected out and processed for quantification of gene expression changes in pro and anti-inflammatory cytokines. Overall, the findings of this study indicate that LPS-induced pro-inflammatory cytokine, TNF-α and IL-1β, secretion and gene expression is down-regulated in C8-B4 microglial cells treated with Iloprost. Furthermore, there was a significant up-regulation in the expression of anti-inflammatory genes, particularly ARG-1, CD206, BDNF and CREB in response to Iloprost treatment following LPS-induced inflammation. This study is also the first to confirm M2 microglial polarization with Iloprost treatment in both resting and LPS treated cells. However, hypermethylation at CREB and BDNF promoter regions was observed 24 hours after Iloprost treatment. Additionally, Iloprost reversed hypomethylation at the BDNF promoter region that had been induced by LPS treatment. The rodent model also indicated a downregulation in the pro-inflammatory cytokine, IL-1β, expression and upregulation of BDNF transcription in T.b brucei infected mice treated with repeated doses of Iloprost. In conclusion, determining the immunomodulatory roles of Iloprost in both in vitro and in vivo models of neuroinflammation could assist in the development of alternative therapy for neurodegenerative disease. , Thesis (MSc) -- Faculty of Science, School of Biomolecular & Chemical Sciences, 2024
- Full Text:
- Date Issued: 2024-12
Conflict management mechanisms for workplace harassment: a case study of a provincial government department of basic education in Johannesburg, South Africa
- Authors: Monakali, Robin
- Date: 2024-12
- Subjects: Conflict management -- South Africa , Bullying in the workplace , Harassment
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/70353 , vital:78342
- Description: Workplace harassment remains a significant concern globally, affecting organizational culture and employee well-being. This study aims to develop an integrated conflict management framework to manage workplace harassment in a selected provincial government department in Johannesburg, Gauteng province. The theoretical frameworks guiding this study included organizational theory, socio-cultural theory, and intersectional feminism. Through a mixed methods approach, which involved combining qualitative and quantitative research methods, this research examines the mechanisms in place to deal with workplace harassment in a selected provincial government department. The qualitative research method that was used comprised online, semi-structured, individual interviews with four Human Resource managers, four departmental managers, four line managers and four non-management employees and the quantitative research method involved the completion of self-administered questionnaires by 153 employees from the provincial government department. The researcher used a purposive sampling design for the interviews and simple random sampling for the questionnaires. The findings reveal that the department has internal structures in place to address harassment, yet a gap that was identified was the implementation and application of the policy as many cases go underreported or unresolved. A novel, integrated conflict management framework was developed, which emphasizes both prevention and intervention strategies to deal with workplace harassment. This study adds to existing knowledge of workplace harassment and can also serve as a reference point for further research undertaken by individuals, policymakers, and scholars. , Thesis (PhD) -- Faculty of Humanities, School of Governmental and Social Sciences, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Monakali, Robin
- Date: 2024-12
- Subjects: Conflict management -- South Africa , Bullying in the workplace , Harassment
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/70353 , vital:78342
- Description: Workplace harassment remains a significant concern globally, affecting organizational culture and employee well-being. This study aims to develop an integrated conflict management framework to manage workplace harassment in a selected provincial government department in Johannesburg, Gauteng province. The theoretical frameworks guiding this study included organizational theory, socio-cultural theory, and intersectional feminism. Through a mixed methods approach, which involved combining qualitative and quantitative research methods, this research examines the mechanisms in place to deal with workplace harassment in a selected provincial government department. The qualitative research method that was used comprised online, semi-structured, individual interviews with four Human Resource managers, four departmental managers, four line managers and four non-management employees and the quantitative research method involved the completion of self-administered questionnaires by 153 employees from the provincial government department. The researcher used a purposive sampling design for the interviews and simple random sampling for the questionnaires. The findings reveal that the department has internal structures in place to address harassment, yet a gap that was identified was the implementation and application of the policy as many cases go underreported or unresolved. A novel, integrated conflict management framework was developed, which emphasizes both prevention and intervention strategies to deal with workplace harassment. This study adds to existing knowledge of workplace harassment and can also serve as a reference point for further research undertaken by individuals, policymakers, and scholars. , Thesis (PhD) -- Faculty of Humanities, School of Governmental and Social Sciences, 2024
- Full Text:
- Date Issued: 2024-12
Construction material waste control success model for the construction industry
- Authors: Musah, Abdul Razak
- Date: 2024-12
- Subjects: Construction industry -- Materials management , Construction industry -- Management , Construction industry -- Environmental aspects
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/68796 , vital:77114
- Description: Economic sustainability and reconstruction in many economies rely heavily on the construction sector and remain strategic tools for governments and industries worldwide. Excessive construction costs and materials waste among some construction companies are rampant in the construction sector. Most of this waste is poorly managed, thus triggering significant project failure problems, leading to the project stakeholders losing the value of their investment. This concern advocate for effective control of construction material to avoid wastage. The primary objective of this study was to develop a Construction Waste Material Control (CWMC) model to be used by construction project professionals throughout the Project Management (PM) phases: initiation, planning, execution, monitoring, control and closure. Significant literature on construction materials waste, Project Management (PM) processes, and project performance regarding poor waste management and project failure was reviewed. This literature review was conducted to identify factors affecting Construction Waste Material Control (CWMC). These factors were identified and defined together with their respective contributions to the model. A quantitative survey instrument (questionnaire) was used to obtain information from construction sector professionals. A total of 213 questionnaire were received and administered for the study. Structural Equation Model (SEM) SEM was used to analyse the questionnaire data, and thereby assisting the research to clearly define latent constructs statistically significant to the (CWMC) model. The finding was that, the factors identified to have impact on CWMC are Project Initiation Phase Tools (PIPTs), Project Planning Phase Tools (PPPTs), project failure/success factors (PFFs), Project Execution Phase Tools (PEPTs), Project Monitoring and Control Phase Tools (PMCPTs), Construction waste material Control (CWMC) policy and Project Management (PM) competence. The supported hypotheses also authenticated these factors. Introducing the model into the construction sector provides another dimension to CWMC. By establishing the aforementioned factors, the model gives construction professionals precise CWMC predictive accuracy. As the model reliability test of 0.734 to 0.972 satisfied the theoretical threshold and goodness of fit of 0.912 of Normed fit index respectively. The model is the first of its kind and contributes significantly to the construction sector’s existing body of knowledge. , Thesis (PhD) -- Faculty of Engineering, the Built Environment, and Technology, School of Built Environment and Civil Engineering, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Musah, Abdul Razak
- Date: 2024-12
- Subjects: Construction industry -- Materials management , Construction industry -- Management , Construction industry -- Environmental aspects
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/68796 , vital:77114
- Description: Economic sustainability and reconstruction in many economies rely heavily on the construction sector and remain strategic tools for governments and industries worldwide. Excessive construction costs and materials waste among some construction companies are rampant in the construction sector. Most of this waste is poorly managed, thus triggering significant project failure problems, leading to the project stakeholders losing the value of their investment. This concern advocate for effective control of construction material to avoid wastage. The primary objective of this study was to develop a Construction Waste Material Control (CWMC) model to be used by construction project professionals throughout the Project Management (PM) phases: initiation, planning, execution, monitoring, control and closure. Significant literature on construction materials waste, Project Management (PM) processes, and project performance regarding poor waste management and project failure was reviewed. This literature review was conducted to identify factors affecting Construction Waste Material Control (CWMC). These factors were identified and defined together with their respective contributions to the model. A quantitative survey instrument (questionnaire) was used to obtain information from construction sector professionals. A total of 213 questionnaire were received and administered for the study. Structural Equation Model (SEM) SEM was used to analyse the questionnaire data, and thereby assisting the research to clearly define latent constructs statistically significant to the (CWMC) model. The finding was that, the factors identified to have impact on CWMC are Project Initiation Phase Tools (PIPTs), Project Planning Phase Tools (PPPTs), project failure/success factors (PFFs), Project Execution Phase Tools (PEPTs), Project Monitoring and Control Phase Tools (PMCPTs), Construction waste material Control (CWMC) policy and Project Management (PM) competence. The supported hypotheses also authenticated these factors. Introducing the model into the construction sector provides another dimension to CWMC. By establishing the aforementioned factors, the model gives construction professionals precise CWMC predictive accuracy. As the model reliability test of 0.734 to 0.972 satisfied the theoretical threshold and goodness of fit of 0.912 of Normed fit index respectively. The model is the first of its kind and contributes significantly to the construction sector’s existing body of knowledge. , Thesis (PhD) -- Faculty of Engineering, the Built Environment, and Technology, School of Built Environment and Civil Engineering, 2024
- Full Text:
- Date Issued: 2024-12
Consumer online shopping behaviour in South Africa
- Authors: Klassen, Cindy
- Date: 2024-12
- Subjects: Electronic commerce -- South Africa , Consumer behavior -- South Africa , Customer services -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70220 , vital:78330
- Description: Online shopping is the ability to purchase goods or services online through the use of the Internet on various sites, either directly from suppliers or through third party sites. Adoption to Online Shopping has seen a steady increase over the last 20 years. Each year consumers seem to become more and more au fait with the concept. This is a trend that has grown in adoption globally and the South African consumer is no different. There are however reasons that influence faster adoption and retailers may also want to understand how important having physical stores still are as these have impacts on the bottom line and profits. Previous studies have investigated the history of online shopping. The reasons as to how and why it is becoming a growing trend as well as what categories consumers prefer to shop online. Other highly researched topics are the factors that inhibit online shopping and the benefits of online shopping. In this study, the focus is on the consumer and how they experience online shopping. This has been identified as the dependent factor. Factors that influence the online shopping experience and thus the independent factors have been identified as Advertising Communication, Trust, Instore Shopping Behaviour and Online Shopping Benefits. The study draws on elements of the Technology Acceptance Model to gain a better understanding on the acceptance of technologies’ influence on online shopping. A sample of 307 respondents completed the questionnaire for this study through convenience sampling. The questionnaire was distributed through business and study networks across South Africa including the Nelson Mandela University Business School. Through this distribution it is evident that most respondents live in urban areas across South Africa and have a postgraduate qualification, which may not be most representative of the South African population. A study needs to take place in future as this sample does not consider the lower income shopper’s experience of online shopping. The results of this study indicate that the independent factor of Online Shopping Benefits has a significantly positive relationship on the Online Shopping Experience which means for practitioners that are trying to grow online shopping, a strong emphasis must be placed on the benefits that consumers are drawn to by v online shopping. These benefits may differ based on the target audience thus it is important for business owners to understand the benefits specific to each target audience. Instore Shopping Behaviour had a negative relationship with Online Shopping Experience, illustrating that the online shopping experience may deter consumers who are attracted to the hedonic behaviours of instore shopping. Furthermore, there appears to be a growing level of trust amongst South African consumers who shop online which may be a reason that online shopping sales revenue continues to increase year on year. Managerial recommendations provide an opportunity for practitioners who want to grow online sales revenue practical solutions to implement. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Klassen, Cindy
- Date: 2024-12
- Subjects: Electronic commerce -- South Africa , Consumer behavior -- South Africa , Customer services -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70220 , vital:78330
- Description: Online shopping is the ability to purchase goods or services online through the use of the Internet on various sites, either directly from suppliers or through third party sites. Adoption to Online Shopping has seen a steady increase over the last 20 years. Each year consumers seem to become more and more au fait with the concept. This is a trend that has grown in adoption globally and the South African consumer is no different. There are however reasons that influence faster adoption and retailers may also want to understand how important having physical stores still are as these have impacts on the bottom line and profits. Previous studies have investigated the history of online shopping. The reasons as to how and why it is becoming a growing trend as well as what categories consumers prefer to shop online. Other highly researched topics are the factors that inhibit online shopping and the benefits of online shopping. In this study, the focus is on the consumer and how they experience online shopping. This has been identified as the dependent factor. Factors that influence the online shopping experience and thus the independent factors have been identified as Advertising Communication, Trust, Instore Shopping Behaviour and Online Shopping Benefits. The study draws on elements of the Technology Acceptance Model to gain a better understanding on the acceptance of technologies’ influence on online shopping. A sample of 307 respondents completed the questionnaire for this study through convenience sampling. The questionnaire was distributed through business and study networks across South Africa including the Nelson Mandela University Business School. Through this distribution it is evident that most respondents live in urban areas across South Africa and have a postgraduate qualification, which may not be most representative of the South African population. A study needs to take place in future as this sample does not consider the lower income shopper’s experience of online shopping. The results of this study indicate that the independent factor of Online Shopping Benefits has a significantly positive relationship on the Online Shopping Experience which means for practitioners that are trying to grow online shopping, a strong emphasis must be placed on the benefits that consumers are drawn to by v online shopping. These benefits may differ based on the target audience thus it is important for business owners to understand the benefits specific to each target audience. Instore Shopping Behaviour had a negative relationship with Online Shopping Experience, illustrating that the online shopping experience may deter consumers who are attracted to the hedonic behaviours of instore shopping. Furthermore, there appears to be a growing level of trust amongst South African consumers who shop online which may be a reason that online shopping sales revenue continues to increase year on year. Managerial recommendations provide an opportunity for practitioners who want to grow online sales revenue practical solutions to implement. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
Criteria for effective short-term rental business venture property selection in Nelson Mandela Bay
- Authors: Theunissen, Melanie
- Date: 2024-12
- Subjects: Real estate investment -- Rental property -- South Africa , Property investment -- Real estate business -- South Africa , Small business -- Management
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/69890 , vital:78143
- Description: Short-term rental (STR) accommodations thrive in the online sharing economy and are influenced by market trends and regulations and vary in location. Success hinges on careful planning, continuous management and fulfilling guest expectations. There is limited research on the types of properties that succeed in the STR business. Additionally, STR’s are regulated, competitive and entail financial planning which can offer both lucrative income potential and high expenses. This treatise is an effort to evaluate the criteria for property selection for STR’s as a business in Nelson Mandela Bay. The research approach for this study is positivistic. A literature review has been conducted to determine the existing status of STR studies relating to the business industry. The literature review allowed the formation of criteria which was tested with quantitative methods consisting of data collection, a questionnaire and an analysis of the statistics. This assessment clearly supported STR as a viable business venture. Based on the research study, criteria were created to help STR owners select the right property for STR. The four main considerations in STR accommodation business in this criteria framework included location, type and size of the property, features and amenities and safety and security. The research confirmed that in the STR market, these variables are proposed as key focal point for business owners to focus on and to positively affect the types of property that are purchased to grow the STR business. As a result, create favourable bottom line returns. In agreement with the literature that is reviewed and the outcomes of this treatise, by effectively addressing the criteria, the business owners of STR’s will create a criteria model that is helpful to purchase the most suitable property for a STR business. Certain key findings from the research found it to be true that you can improve property selection decision making through the identification of relevant criteria that can assist STR business investors and managers. It is proposed that the criteria is examined to provide further advancement to the STR industry. The recommendations include further improving the criteria by providing additional information about the STR business behaviours connected to each variable and increasing the scope of the study to more than just one sample from mainly the Eastern Cape in South Africa. , Thesis (MBA) -- Faculty Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Theunissen, Melanie
- Date: 2024-12
- Subjects: Real estate investment -- Rental property -- South Africa , Property investment -- Real estate business -- South Africa , Small business -- Management
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/69890 , vital:78143
- Description: Short-term rental (STR) accommodations thrive in the online sharing economy and are influenced by market trends and regulations and vary in location. Success hinges on careful planning, continuous management and fulfilling guest expectations. There is limited research on the types of properties that succeed in the STR business. Additionally, STR’s are regulated, competitive and entail financial planning which can offer both lucrative income potential and high expenses. This treatise is an effort to evaluate the criteria for property selection for STR’s as a business in Nelson Mandela Bay. The research approach for this study is positivistic. A literature review has been conducted to determine the existing status of STR studies relating to the business industry. The literature review allowed the formation of criteria which was tested with quantitative methods consisting of data collection, a questionnaire and an analysis of the statistics. This assessment clearly supported STR as a viable business venture. Based on the research study, criteria were created to help STR owners select the right property for STR. The four main considerations in STR accommodation business in this criteria framework included location, type and size of the property, features and amenities and safety and security. The research confirmed that in the STR market, these variables are proposed as key focal point for business owners to focus on and to positively affect the types of property that are purchased to grow the STR business. As a result, create favourable bottom line returns. In agreement with the literature that is reviewed and the outcomes of this treatise, by effectively addressing the criteria, the business owners of STR’s will create a criteria model that is helpful to purchase the most suitable property for a STR business. Certain key findings from the research found it to be true that you can improve property selection decision making through the identification of relevant criteria that can assist STR business investors and managers. It is proposed that the criteria is examined to provide further advancement to the STR industry. The recommendations include further improving the criteria by providing additional information about the STR business behaviours connected to each variable and increasing the scope of the study to more than just one sample from mainly the Eastern Cape in South Africa. , Thesis (MBA) -- Faculty Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
Development of density-dependent and density-independent competition models to understand single tree growth responses in eucalyptus stands
- Authors: Kepe, Lulama Patrick
- Date: 2024-12
- Subjects: Forests and forestry -- Mathematical models , Trees -- Growth -- Mathematical models , Eucalyptus grandis
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/68906 , vital:77161
- Description: In commercial forest production, predicted yields based on mensuration recommendations are seldom realized, and minimal silvicultural standards based on results from trial blocks do not account for the relationship between initial planting density and final stocking. Growth models designed to investigate management options must employ competition indices to provide reliable predictions under extreme silviculture. The competition a tree experiences until the day of harvest is a strong driver for quality and volume of timber. Hence, this turns the regulation of competition into an integral part of silviculture. According to Little et al. (2003), it is known that, at some stage after canopy closure, individual trees in a stand will begin to compete for resources. To investigate competition amongst individual trees, a re-purposed Bayesian mixed effects model, similar in characteristics to a Sire model used for estimating breeding values, is proposed. In animal breeding models, the Sire Model allows for the inclusion of a numerator relationship matrix containing inbreeding coefficients. In a similar way, documented competition indices are included in the model in an attempt to estimate posterior probabilities of specifically selected individual trees being the strongest growers during different stages in the tree growth cycle. Estimated tree growth indices were determined and used to make probability statements in order to rank the individually selected trees based on the amount of growth observed. A tree growth index is a measurement of a tree’s average growth performance in relation to the average growth performance of all trees on the same plot. As different competition indices are introduced into the model, changes in the probabilities are observed and compared to what is visually observed on the plot, i.e. if the tree with the highest probability of being the strongest grower, is actually not necessarily the largest tree of the group of selected trees, but rather the tree that presented the largest amount of growth of the selected group of trees during that specific growth season. From a randomly selected plot, a group of neighboring trees were randomly selected. Four specifically selected target trees were then identified from this group of 25 selected trees, and analyzed. For this discussion, for example, from our randomly selected group of 25 neighboring trees, tree 54, tree 56, tree 86, and tree 88 were specifically selected for further analysis. For these specifically selected trees, marginal posterior densities for the variance components and random effects were then estimated using the Gibbs Sampler, where competition between the trees was assumed present, as well as for the case where it was assumed that no competition takes place between the individually selected trees. In the latter case, an identity matrix was utilized in the Gibbs sampling algorithm where it was assumed that there is no competition between the trees. Both a distance independent competition index (Lorimer,1983), and a distance dependent index (Hegyi, 1974), were used to generate the numerator relationship matrix A that was used by the Gibbs sampling algorithm in the case where competition was assumed between individual trees. Also a new distance dependent index was proposed and tested in this study as well. Results from the selected plot, with a 1500 stems per hectare (sph) density, indicated that there were no significant differences in the average growth between these selected trees. However, the marginal posterior densities of the fixed effects indicated that there was a significant difference in the average growth rates between the base level conditions and other levels determined for each of these fixed effect factors for the selected trees, since their 95% equal tails credibility intervals, did not contain zero. This therefore indicated that the specific treatment applied on the plot, had a significant effect on the individual tree growth. Results when competition was assumed present, revealed that the estimated marginal posterior densities for the error variance as well as tree variance, were severely positively skewed. , Thesis (PhD) -- Faculty of Science, School of Natural Resource Science & Management, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Kepe, Lulama Patrick
- Date: 2024-12
- Subjects: Forests and forestry -- Mathematical models , Trees -- Growth -- Mathematical models , Eucalyptus grandis
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/68906 , vital:77161
- Description: In commercial forest production, predicted yields based on mensuration recommendations are seldom realized, and minimal silvicultural standards based on results from trial blocks do not account for the relationship between initial planting density and final stocking. Growth models designed to investigate management options must employ competition indices to provide reliable predictions under extreme silviculture. The competition a tree experiences until the day of harvest is a strong driver for quality and volume of timber. Hence, this turns the regulation of competition into an integral part of silviculture. According to Little et al. (2003), it is known that, at some stage after canopy closure, individual trees in a stand will begin to compete for resources. To investigate competition amongst individual trees, a re-purposed Bayesian mixed effects model, similar in characteristics to a Sire model used for estimating breeding values, is proposed. In animal breeding models, the Sire Model allows for the inclusion of a numerator relationship matrix containing inbreeding coefficients. In a similar way, documented competition indices are included in the model in an attempt to estimate posterior probabilities of specifically selected individual trees being the strongest growers during different stages in the tree growth cycle. Estimated tree growth indices were determined and used to make probability statements in order to rank the individually selected trees based on the amount of growth observed. A tree growth index is a measurement of a tree’s average growth performance in relation to the average growth performance of all trees on the same plot. As different competition indices are introduced into the model, changes in the probabilities are observed and compared to what is visually observed on the plot, i.e. if the tree with the highest probability of being the strongest grower, is actually not necessarily the largest tree of the group of selected trees, but rather the tree that presented the largest amount of growth of the selected group of trees during that specific growth season. From a randomly selected plot, a group of neighboring trees were randomly selected. Four specifically selected target trees were then identified from this group of 25 selected trees, and analyzed. For this discussion, for example, from our randomly selected group of 25 neighboring trees, tree 54, tree 56, tree 86, and tree 88 were specifically selected for further analysis. For these specifically selected trees, marginal posterior densities for the variance components and random effects were then estimated using the Gibbs Sampler, where competition between the trees was assumed present, as well as for the case where it was assumed that no competition takes place between the individually selected trees. In the latter case, an identity matrix was utilized in the Gibbs sampling algorithm where it was assumed that there is no competition between the trees. Both a distance independent competition index (Lorimer,1983), and a distance dependent index (Hegyi, 1974), were used to generate the numerator relationship matrix A that was used by the Gibbs sampling algorithm in the case where competition was assumed between individual trees. Also a new distance dependent index was proposed and tested in this study as well. Results from the selected plot, with a 1500 stems per hectare (sph) density, indicated that there were no significant differences in the average growth between these selected trees. However, the marginal posterior densities of the fixed effects indicated that there was a significant difference in the average growth rates between the base level conditions and other levels determined for each of these fixed effect factors for the selected trees, since their 95% equal tails credibility intervals, did not contain zero. This therefore indicated that the specific treatment applied on the plot, had a significant effect on the individual tree growth. Results when competition was assumed present, revealed that the estimated marginal posterior densities for the error variance as well as tree variance, were severely positively skewed. , Thesis (PhD) -- Faculty of Science, School of Natural Resource Science & Management, 2024
- Full Text:
- Date Issued: 2024-12
Economic diversification and socio-economic development: a case of Namibia
- Authors: Fikunawa, Brigitte
- Date: 2024-12
- Subjects: Diversification in industry , Economic development -- Namibia , Namibia -- Economic conditions
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/70264 , vital:78334
- Description: Economic diversification has been at the forefront of many countries’ socio-economic development agendas, especially resource-rich developing countries. It is seen as a tool for attaining socio-economic development. After independence as a strategy to resolve socio-economic challenges, most developing economies like Namibia implemented policies and strategies enabling economic diversification. This study provides an empirical analysis of Namibia’s economic diversification and socio-economic development between 1990 and 2021. The study used a concurrent mixed research methodology involving quantitative secondary and qualitative interview-based primary data to assist in filling any gaps left by either methodology. The interviews helped expand and validate the secondary data results. The quantitative component of the study focuses on determining the level of economic diversification, the drivers of that diversification and the effect of economic diversification on socio-economic development. The study used the Tress and Ogive indices to proxy for economic diversification, while employment, poverty reduction and economic growth represent socio-economic development. Reading from these economic diversification measures, Namibia’s economy is relatively diversified but remains in the initial stage, with Tress and Ogive indices levels of 48.09/6.03. The study also found that in the long run, foreign direct investment (FDI), education and institutional quality lead to increased economic diversification while inflation discourage economic diversification. In the short run, FDI and education enhances diversification while inflation, financial sector development and earnings from natural resources lead to a decline in economic diversification. In examining the effect of economic diversification on socio-economic development, the results show that it has a positive influence on employment creation, poverty reduction and economic growth in the long and the short term. So overall the study found that economic diversification contributes positively to socio-economic development. To validate the quantitative results, six senior executives from five entities which includes ministries, government agencies and the private sector were selected purposively for interviews on their perception of economic diversification in Namibia and the data were analysed thematically. The results were inconclusive with regard to the effectiveness of the enabling policies. The participants agreed the enabling policies had contributed to employment, poverty reduction, income equality and economic growth. However, more needs to be done, like creating value chain-connected sectors that create seasonal employment, for the contribution to be sustainable. The study also found that the cost of doing business (mainly taxation and the cost of water and electricity); policies and institutional frameworks (like immigration, trade and investment laws); competitiveness of the economy in terms of its size, quality of human capital, manufacturing capacity and economic uncertainty are the leading challenges affecting the progress of Namibia’s economic diversification process. This researcher drew up several recommendations for the Namibian government to continue enhancing economic diversification to address the socio-economic challenges of unemployment, poverty and income inequality through investment in productive areas of the manufacturing and services sectors which can contribute to growth and employment. The government also needs to address the challenges hindering the progress of economic diversification in the country to create an environment that can foster economic diversification. The study recommends targeted intervention to enhance the attractiveness of other sectors so as to wean the economy off its high dependence on the primary sector through the provision of both fiscal and non-fiscal incentives. The required human capital development should be harnessed through investment in capabilities like vocational skills that are needed for economic diversification and socio-economic development to be achieved. Good governance should be attained by fighting corruption to enhance investment confidence. It further recommends that Namibia ratifies and implement the SADC protocol on trade and the African Continental Free Trade Area (AfCFTA) agreement to increase market accessibility and address the country’s market size, which is currently uncompetitive for investment. , Thesis (PhD) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Fikunawa, Brigitte
- Date: 2024-12
- Subjects: Diversification in industry , Economic development -- Namibia , Namibia -- Economic conditions
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/70264 , vital:78334
- Description: Economic diversification has been at the forefront of many countries’ socio-economic development agendas, especially resource-rich developing countries. It is seen as a tool for attaining socio-economic development. After independence as a strategy to resolve socio-economic challenges, most developing economies like Namibia implemented policies and strategies enabling economic diversification. This study provides an empirical analysis of Namibia’s economic diversification and socio-economic development between 1990 and 2021. The study used a concurrent mixed research methodology involving quantitative secondary and qualitative interview-based primary data to assist in filling any gaps left by either methodology. The interviews helped expand and validate the secondary data results. The quantitative component of the study focuses on determining the level of economic diversification, the drivers of that diversification and the effect of economic diversification on socio-economic development. The study used the Tress and Ogive indices to proxy for economic diversification, while employment, poverty reduction and economic growth represent socio-economic development. Reading from these economic diversification measures, Namibia’s economy is relatively diversified but remains in the initial stage, with Tress and Ogive indices levels of 48.09/6.03. The study also found that in the long run, foreign direct investment (FDI), education and institutional quality lead to increased economic diversification while inflation discourage economic diversification. In the short run, FDI and education enhances diversification while inflation, financial sector development and earnings from natural resources lead to a decline in economic diversification. In examining the effect of economic diversification on socio-economic development, the results show that it has a positive influence on employment creation, poverty reduction and economic growth in the long and the short term. So overall the study found that economic diversification contributes positively to socio-economic development. To validate the quantitative results, six senior executives from five entities which includes ministries, government agencies and the private sector were selected purposively for interviews on their perception of economic diversification in Namibia and the data were analysed thematically. The results were inconclusive with regard to the effectiveness of the enabling policies. The participants agreed the enabling policies had contributed to employment, poverty reduction, income equality and economic growth. However, more needs to be done, like creating value chain-connected sectors that create seasonal employment, for the contribution to be sustainable. The study also found that the cost of doing business (mainly taxation and the cost of water and electricity); policies and institutional frameworks (like immigration, trade and investment laws); competitiveness of the economy in terms of its size, quality of human capital, manufacturing capacity and economic uncertainty are the leading challenges affecting the progress of Namibia’s economic diversification process. This researcher drew up several recommendations for the Namibian government to continue enhancing economic diversification to address the socio-economic challenges of unemployment, poverty and income inequality through investment in productive areas of the manufacturing and services sectors which can contribute to growth and employment. The government also needs to address the challenges hindering the progress of economic diversification in the country to create an environment that can foster economic diversification. The study recommends targeted intervention to enhance the attractiveness of other sectors so as to wean the economy off its high dependence on the primary sector through the provision of both fiscal and non-fiscal incentives. The required human capital development should be harnessed through investment in capabilities like vocational skills that are needed for economic diversification and socio-economic development to be achieved. Good governance should be attained by fighting corruption to enhance investment confidence. It further recommends that Namibia ratifies and implement the SADC protocol on trade and the African Continental Free Trade Area (AfCFTA) agreement to increase market accessibility and address the country’s market size, which is currently uncompetitive for investment. , Thesis (PhD) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2024
- Full Text:
- Date Issued: 2024-12
Effects of supply chain disruptions on alcohol consumption behaviour in a South African township
- Authors: Sipamla, Noluthando
- Date: 2024-12
- Subjects: Business logistics , Inventory control , Alcoholism
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/69913 , vital:78172
- Description: This study investigated the effect of supply chain disruptions on alcohol consumer consumption behaviour in the Eastern Cape Province, but with the specific reference to Mdantsane Township in the Buffalo City Municipality. A quantitative methodology was employed, and self-administered questionnaires were used to collect data. The results of the study revealed that: disruptions increase the risk of the company; disruptions have a significant negative impact on profitability; disruptions have a crippling effect on performance because firms take longer to recover from disruptions; and disruptions have a negative impact on stock price, profitability, and share price volatility across the board. The study recommends diversification of alcohol supply chains to mitigate the impact of disruptions, establish robust monitoring and surveillance systems to track changes in alcohol consumption patterns following supply chain disruptions and consider implementing price regulation and taxation policies to moderate alcohol consumption, particularly during periods of supply chain disruptions. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Sipamla, Noluthando
- Date: 2024-12
- Subjects: Business logistics , Inventory control , Alcoholism
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/69913 , vital:78172
- Description: This study investigated the effect of supply chain disruptions on alcohol consumer consumption behaviour in the Eastern Cape Province, but with the specific reference to Mdantsane Township in the Buffalo City Municipality. A quantitative methodology was employed, and self-administered questionnaires were used to collect data. The results of the study revealed that: disruptions increase the risk of the company; disruptions have a significant negative impact on profitability; disruptions have a crippling effect on performance because firms take longer to recover from disruptions; and disruptions have a negative impact on stock price, profitability, and share price volatility across the board. The study recommends diversification of alcohol supply chains to mitigate the impact of disruptions, establish robust monitoring and surveillance systems to track changes in alcohol consumption patterns following supply chain disruptions and consider implementing price regulation and taxation policies to moderate alcohol consumption, particularly during periods of supply chain disruptions. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2024
- Full Text:
- Date Issued: 2024-12
Examining the effect of government expenditure on economic growth in South Africa
- Authors: Mafuya, Afika
- Date: 2024-12
- Subjects: Government spending policy -- South Africa , Economic development -- South Africa , South Africa -- Appropriations and expenditures
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70177 , vital:78308
- Description: This treatise assesses the effect of government expenditure on economic growth in South Africa. The results of most extant empirical studies indicate that government expenditure has a negative effect on economic growth. Augmented Dickey-Fuller and Phillips-Perron tests were conducted to determine stationarity and order of integration. The ADF results indicated that government expenditure (GXE), government infrastructure expenditure (GEIE), government social infrastructure (GSIE), and GDP are stationary after first difference. The Johansen co-integration tests (maximum Eigenvalue and trace tests) indicated one co-integrating relationship between social infrastructure, economic infrastructure, government expenditure, and economic growth. VECM was estimated because of the presence of co-integration between variables for the period 1970-2021. The long run results indicate that government expenditure and economic growth have an effect, but the effect is very low as the speed of adjustment, 0.013% is also slow. on the other hand social infrastructure expenditure has a negative effect on economic growth. This study conducted diagnostic checks- the lagrange multiplier correlation test, normality tests and hetero-scedasticity tests to test the properties of the model and expenditure to components that contribute most the country's productivity and economic growth, which in this case is economic infrastructure. , Thesis (MCom) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2024
- Full Text: false
- Date Issued: 2024-12
- Authors: Mafuya, Afika
- Date: 2024-12
- Subjects: Government spending policy -- South Africa , Economic development -- South Africa , South Africa -- Appropriations and expenditures
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/70177 , vital:78308
- Description: This treatise assesses the effect of government expenditure on economic growth in South Africa. The results of most extant empirical studies indicate that government expenditure has a negative effect on economic growth. Augmented Dickey-Fuller and Phillips-Perron tests were conducted to determine stationarity and order of integration. The ADF results indicated that government expenditure (GXE), government infrastructure expenditure (GEIE), government social infrastructure (GSIE), and GDP are stationary after first difference. The Johansen co-integration tests (maximum Eigenvalue and trace tests) indicated one co-integrating relationship between social infrastructure, economic infrastructure, government expenditure, and economic growth. VECM was estimated because of the presence of co-integration between variables for the period 1970-2021. The long run results indicate that government expenditure and economic growth have an effect, but the effect is very low as the speed of adjustment, 0.013% is also slow. on the other hand social infrastructure expenditure has a negative effect on economic growth. This study conducted diagnostic checks- the lagrange multiplier correlation test, normality tests and hetero-scedasticity tests to test the properties of the model and expenditure to components that contribute most the country's productivity and economic growth, which in this case is economic infrastructure. , Thesis (MCom) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2024
- Full Text: false
- Date Issued: 2024-12
Experiences of accoucheurs caring for women during confinement in public maternity units in the O.R. Tambo District Municipality
- Authors: Wabane, Malibongwe
- Date: 2024-12
- Subjects: Midwifery -- South Africa -- Eastern Cape , Labor (Obstetrics) -- South Africa -- Eastern Cape , Hospital care -- South Africa -- Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/69782 , vital:78034
- Description: Midwifery is a health science profession that deals with women in their confinement period, including the caring of new-borns. Historically, the midwifery profession has evolved from being a female-dominated profession to an occupation followed by both males and females. However, accoucheurs working in public maternity units face various challenges, such as a lack of support and discrimination from their female counterparts and women during confinement. These challenges are based mainly on tradition, religion, and the history of midwifery, a female-dominant profession. The potential effects of these challenges can be seen when women during confinement refuse maternal care from accoucheurs. As a result of this prejudice, accoucheurs may be unable to practice their midwifery skills and may choose other disciplines involving less intimate care. Such acts of refusal of care by women during confinement and these various challenges faced by accoucheurs in public maternity units are common in rural areas. The O.R. Tambo District Municipality (ORTDM) comprises predominantly of rural areas where culture and tradition play an essential role in the community’s life. This study employed a qualitative research design with an explorative, descriptive, and contextual approach to gain a deeper understanding of the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM. The purpose of this study was to explore and describe the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM to make recommendations to nursing managers regarding the provision of optimal support to accoucheurs working in the rural Eastern Cape. The target population of the study was all accoucheurs working in public maternity units in the ORTDM. Snowball sampling, a non-probability sampling method, was used to select participants who met the inclusion criteria and were voluntarily willing to participate in the study. The data collection method used was one-on-one semistructured interviews, which were also captured using a digital voice recorder. Field notes were used during data collection to enhance the researcher’s understanding of accoucheurs’ nonverbal experiences. The sample size, which was 12 accoucheurs, was determined by data saturation. Data was transcribed verbatim, and Braun and Clark’s (2006) steps of reflexive thematic analysis (RTA) were used as a framework for data analysis. Lincoln and Guba’s model of trustworthiness was used to maintain the quality of the study by employing credibility, transferability, confirmability, and dependability (Lincoln and Guba, 1985). The ethical principles that guided this study with human participants were the principles of respect for persons, beneficence, non-maleficence, and justice as outlined in the Belmont Report and its application (2015:14) Three main themes emerged from the data analysis, namely: • Theme 1: Accoucheurs experienced specific factors that enabled them to care for women during confinement in public maternity units. • Theme 2: Accoucheurs identified barriers that disabled them in caring for women during confinement in public maternity units. • Theme 3: Recommendations for nurse managers by accoucheurs to optimize their ability to care for women during confinement in public maternity units. Direct quotations from the raw data and relevant literature supported the research study results and were discussed in-depth in Chapter Four. Various recommendations were discussed in Chapter Five of this study that present options for nurse managers to optimize the support for accoucheurs who were caring for women during confinement in public maternity units.Midwifery is a health science profession that deals with women in their confinement period, including the caring of new-borns. Historically, the midwifery profession has evolved from being a female-dominated profession to an occupation followed by both males and females. However, accoucheurs working in public maternity units face various challenges, such as a lack of support and discrimination from their female counterparts and women during confinement. These challenges are based mainly on tradition, religion, and the history of midwifery, a female-dominant profession. The potential effects of these challenges can be seen when women during confinement refuse maternal care from accoucheurs. As a result of this prejudice, accoucheurs may be unable to practice their midwifery skills and may choose other disciplines involving less intimate care. Such acts of refusal of care by women during confinement and these various challenges faced by accoucheurs in public maternity units are common in rural areas. The O.R. Tambo District Municipality (ORTDM) comprises predominantly of rural areas where culture and tradition play an essential role in the community’s life. This study employed a qualitative research design with an explorative, descriptive, and contextual approach to gain a deeper understanding of the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM. The purpose of this study was to explore and describe the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM to make recommendations to nursing managers regarding the provision of optimal support to accoucheurs working in the rural Eastern Cape. The target population of the study was all accoucheurs working in public maternity units in the ORTDM. Snowball sampling, a non-probability sampling method, was used to select participants who met the inclusion criteria and were voluntarily willing to participate in the study. The data collection method used was one-on-one semistructured interviews, which were also captured using a digital voice recorder. Field notes were used during data collection to enhance the researcher’s understanding of accoucheurs’ nonverbal experiences. The sample size, which was 12 accoucheurs, was determined by data saturation. Data was transcribed verbatim, and Braun and Clark’s (2006) steps of reflexive thematic analysis (RTA) were used as a framework for data analysis. Lincoln and Guba’s model of trustworthiness was used to maintain the quality of the study by employing credibility, transferability, confirmability, and dependability (Lincoln and Guba, 1985). The ethical principles that guided this study with human participants were the principles of respect for persons, beneficence, non-maleficence, and justice as outlined in the Belmont Report and its application (2015:14) Three main themes emerged from the data analysis, namely: • Theme 1: Accoucheurs experienced specific factors that enabled them to care for women during confinement in public maternity units. • Theme 2: Accoucheurs identified barriers that disabled them in caring for women during confinement in public maternity units. • Theme 3: Recommendations for nurse managers by accoucheurs to optimize their ability to care for women during confinement in public maternity units. Direct quotations from the raw data and relevant literature supported the research study results and were discussed in-depth in Chapter Four. Various recommendations were discussed in Chapter Five of this study that present options for nurse managers to optimize the support for accoucheurs who were caring for women during confinement in public maternity units. , Thesis (MCur) -- Faculty of Health Sciences, School of Clinical Care & Medicinal Sciences, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Wabane, Malibongwe
- Date: 2024-12
- Subjects: Midwifery -- South Africa -- Eastern Cape , Labor (Obstetrics) -- South Africa -- Eastern Cape , Hospital care -- South Africa -- Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/69782 , vital:78034
- Description: Midwifery is a health science profession that deals with women in their confinement period, including the caring of new-borns. Historically, the midwifery profession has evolved from being a female-dominated profession to an occupation followed by both males and females. However, accoucheurs working in public maternity units face various challenges, such as a lack of support and discrimination from their female counterparts and women during confinement. These challenges are based mainly on tradition, religion, and the history of midwifery, a female-dominant profession. The potential effects of these challenges can be seen when women during confinement refuse maternal care from accoucheurs. As a result of this prejudice, accoucheurs may be unable to practice their midwifery skills and may choose other disciplines involving less intimate care. Such acts of refusal of care by women during confinement and these various challenges faced by accoucheurs in public maternity units are common in rural areas. The O.R. Tambo District Municipality (ORTDM) comprises predominantly of rural areas where culture and tradition play an essential role in the community’s life. This study employed a qualitative research design with an explorative, descriptive, and contextual approach to gain a deeper understanding of the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM. The purpose of this study was to explore and describe the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM to make recommendations to nursing managers regarding the provision of optimal support to accoucheurs working in the rural Eastern Cape. The target population of the study was all accoucheurs working in public maternity units in the ORTDM. Snowball sampling, a non-probability sampling method, was used to select participants who met the inclusion criteria and were voluntarily willing to participate in the study. The data collection method used was one-on-one semistructured interviews, which were also captured using a digital voice recorder. Field notes were used during data collection to enhance the researcher’s understanding of accoucheurs’ nonverbal experiences. The sample size, which was 12 accoucheurs, was determined by data saturation. Data was transcribed verbatim, and Braun and Clark’s (2006) steps of reflexive thematic analysis (RTA) were used as a framework for data analysis. Lincoln and Guba’s model of trustworthiness was used to maintain the quality of the study by employing credibility, transferability, confirmability, and dependability (Lincoln and Guba, 1985). The ethical principles that guided this study with human participants were the principles of respect for persons, beneficence, non-maleficence, and justice as outlined in the Belmont Report and its application (2015:14) Three main themes emerged from the data analysis, namely: • Theme 1: Accoucheurs experienced specific factors that enabled them to care for women during confinement in public maternity units. • Theme 2: Accoucheurs identified barriers that disabled them in caring for women during confinement in public maternity units. • Theme 3: Recommendations for nurse managers by accoucheurs to optimize their ability to care for women during confinement in public maternity units. Direct quotations from the raw data and relevant literature supported the research study results and were discussed in-depth in Chapter Four. Various recommendations were discussed in Chapter Five of this study that present options for nurse managers to optimize the support for accoucheurs who were caring for women during confinement in public maternity units.Midwifery is a health science profession that deals with women in their confinement period, including the caring of new-borns. Historically, the midwifery profession has evolved from being a female-dominated profession to an occupation followed by both males and females. However, accoucheurs working in public maternity units face various challenges, such as a lack of support and discrimination from their female counterparts and women during confinement. These challenges are based mainly on tradition, religion, and the history of midwifery, a female-dominant profession. The potential effects of these challenges can be seen when women during confinement refuse maternal care from accoucheurs. As a result of this prejudice, accoucheurs may be unable to practice their midwifery skills and may choose other disciplines involving less intimate care. Such acts of refusal of care by women during confinement and these various challenges faced by accoucheurs in public maternity units are common in rural areas. The O.R. Tambo District Municipality (ORTDM) comprises predominantly of rural areas where culture and tradition play an essential role in the community’s life. This study employed a qualitative research design with an explorative, descriptive, and contextual approach to gain a deeper understanding of the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM. The purpose of this study was to explore and describe the experiences of accoucheurs caring for women during confinement in public maternity units in the ORTDM to make recommendations to nursing managers regarding the provision of optimal support to accoucheurs working in the rural Eastern Cape. The target population of the study was all accoucheurs working in public maternity units in the ORTDM. Snowball sampling, a non-probability sampling method, was used to select participants who met the inclusion criteria and were voluntarily willing to participate in the study. The data collection method used was one-on-one semistructured interviews, which were also captured using a digital voice recorder. Field notes were used during data collection to enhance the researcher’s understanding of accoucheurs’ nonverbal experiences. The sample size, which was 12 accoucheurs, was determined by data saturation. Data was transcribed verbatim, and Braun and Clark’s (2006) steps of reflexive thematic analysis (RTA) were used as a framework for data analysis. Lincoln and Guba’s model of trustworthiness was used to maintain the quality of the study by employing credibility, transferability, confirmability, and dependability (Lincoln and Guba, 1985). The ethical principles that guided this study with human participants were the principles of respect for persons, beneficence, non-maleficence, and justice as outlined in the Belmont Report and its application (2015:14) Three main themes emerged from the data analysis, namely: • Theme 1: Accoucheurs experienced specific factors that enabled them to care for women during confinement in public maternity units. • Theme 2: Accoucheurs identified barriers that disabled them in caring for women during confinement in public maternity units. • Theme 3: Recommendations for nurse managers by accoucheurs to optimize their ability to care for women during confinement in public maternity units. Direct quotations from the raw data and relevant literature supported the research study results and were discussed in-depth in Chapter Four. Various recommendations were discussed in Chapter Five of this study that present options for nurse managers to optimize the support for accoucheurs who were caring for women during confinement in public maternity units. , Thesis (MCur) -- Faculty of Health Sciences, School of Clinical Care & Medicinal Sciences, 2024
- Full Text:
- Date Issued: 2024-12
Exploiting continuous flow technology to develop synthetic processes for active pharmaceutical ingredients: prilocaine and betrixaban
- Authors: Sagandira, Mellisa Brenda
- Date: 2024-12
- Subjects: Pharmaceutical technology , Drug development , Pharmaceutical biotechnology
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/69464 , vital:77259
- Description: The dilemma of providing affordable health care has long haunted African countries due to the continuously growing disease burden as the population increases. Africa accounts for only 3 % of global drug production and imports over 90 % of its life saving medicines at a yearly cost of US$14 billion according to the African Development Bank (AfDB). Attaining Africa’s Agenda 2063, Universal Health Coverage (UHC) and Sustainable development Goal 3 (SDG3) aspirations of ensuring healthy and well-nourished citizens remain difficult given this situation. This over-dependence on imports has led to drug shortages, high pricing, poor quality medicines and unguaranteed supply chains, thus there still remains an unmet need. The advent of the COVID-19 pandemic worsened this situation as many countries curbed exports resulting in a crisis across the continent. Africa experienced high demand of medicines compared to prepandemic level, which threatened the health care of the continent. This situation can be addressed by establishment of local pharmaceutical manufacturing capability through adoption of advanced manufacturing technologies such as continuous flow chemistry. In this research, we therefore seek to exploit continuous flow chemistry, an enabling technology to develop safe and efficient synthetic processes for active pharmaceutical ingredients: prilocaine and betrixaban as case studies. To the best of our knowledge there is no reported work on synthetic processes towards prilocaine and betrixaban under continuous flow conditions, thus this research extensively unearthed interesting continuous flow processes towards these APIs. In a broader view, establishment of local APIs production will ease Africa’s over-dependence on imports, which will in turn address issues such as drug shortages, poor quality and high pricing. This work aims to demonstrate how continuous flow technology can be useful for the establishment of local APIs manufacturing, which will inherently revolutionize medicines availability, affordability and accessibility to the greater population. Chapter one begins with a brief overview on Africa’s disease burden and pharmaceutical supply chain. Continuous flow chemistry is introduced with its benefits and limitations discussed. Lastly a mini review of examples of APIs synthesised in continuous flow is presented. In chapter two, we demonstrate how continuous flow technology can be exploited to develop synthetic processes towards prilocaine as our first case study. This chapter clearly demonstrates how highly exothermic nitration reactions can be safely handled by using continuous flow systems. Additionally, the use of a micro structured mixer facilitated biphasic nitration of toluene to be carried out with enhanced mass transfer, which inherently led to improved selectivity of ortho-nitrotoluene (preferred isomer) to 79 % compared to 59 % achieved in batch mode. A two-step synthesis of ortho-toluidine via biphasic nitration of toluene and nitroreduction was demonstrated with the incorporation of a Zaiput liquid/liquid separator to facilitate in-line separation. Comprehensive optimisation studies were carried out in flow. Prilocaine was synthesised in 74 % overall yield in a 13.6 min residence time for all processes. In chapter three, we demonstrate how continuous flow technology can be exploited to develop synthetic processes towards betrixaban. Synthetic routes towards betrixaban feature two amide bond formation transformations. Pleasingly, we explored multistep chemistry to develop amide synthesis protocols in flow without interruption for work up and isolation. An overall yield of 92 % was achieved to get to key intermediate to betrixaban in 8 min total residence time. Chapter four demonstrates the robustness of developed amide synthesis protocols, a key transformation in synthetic routes towards prilocaine and betrixaban in continuous flow systems. A total of 22 amides were synthesised via flow multistep processes with isolated yields greater than 82 %. All the compounds were characterized using infrared spectroscopy (IR), and nuclear magnetic resonance (NMR). Quantification of the reaction mixtures were carried out using highperformance liquid chromatography (HPLC) and gas chromatography (GC). , Thesis (PhD) -- Faculty of Science, School of Biomolecular & Chemical Sciences, 2024
- Full Text:
- Date Issued: 2024-12
- Authors: Sagandira, Mellisa Brenda
- Date: 2024-12
- Subjects: Pharmaceutical technology , Drug development , Pharmaceutical biotechnology
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/69464 , vital:77259
- Description: The dilemma of providing affordable health care has long haunted African countries due to the continuously growing disease burden as the population increases. Africa accounts for only 3 % of global drug production and imports over 90 % of its life saving medicines at a yearly cost of US$14 billion according to the African Development Bank (AfDB). Attaining Africa’s Agenda 2063, Universal Health Coverage (UHC) and Sustainable development Goal 3 (SDG3) aspirations of ensuring healthy and well-nourished citizens remain difficult given this situation. This over-dependence on imports has led to drug shortages, high pricing, poor quality medicines and unguaranteed supply chains, thus there still remains an unmet need. The advent of the COVID-19 pandemic worsened this situation as many countries curbed exports resulting in a crisis across the continent. Africa experienced high demand of medicines compared to prepandemic level, which threatened the health care of the continent. This situation can be addressed by establishment of local pharmaceutical manufacturing capability through adoption of advanced manufacturing technologies such as continuous flow chemistry. In this research, we therefore seek to exploit continuous flow chemistry, an enabling technology to develop safe and efficient synthetic processes for active pharmaceutical ingredients: prilocaine and betrixaban as case studies. To the best of our knowledge there is no reported work on synthetic processes towards prilocaine and betrixaban under continuous flow conditions, thus this research extensively unearthed interesting continuous flow processes towards these APIs. In a broader view, establishment of local APIs production will ease Africa’s over-dependence on imports, which will in turn address issues such as drug shortages, poor quality and high pricing. This work aims to demonstrate how continuous flow technology can be useful for the establishment of local APIs manufacturing, which will inherently revolutionize medicines availability, affordability and accessibility to the greater population. Chapter one begins with a brief overview on Africa’s disease burden and pharmaceutical supply chain. Continuous flow chemistry is introduced with its benefits and limitations discussed. Lastly a mini review of examples of APIs synthesised in continuous flow is presented. In chapter two, we demonstrate how continuous flow technology can be exploited to develop synthetic processes towards prilocaine as our first case study. This chapter clearly demonstrates how highly exothermic nitration reactions can be safely handled by using continuous flow systems. Additionally, the use of a micro structured mixer facilitated biphasic nitration of toluene to be carried out with enhanced mass transfer, which inherently led to improved selectivity of ortho-nitrotoluene (preferred isomer) to 79 % compared to 59 % achieved in batch mode. A two-step synthesis of ortho-toluidine via biphasic nitration of toluene and nitroreduction was demonstrated with the incorporation of a Zaiput liquid/liquid separator to facilitate in-line separation. Comprehensive optimisation studies were carried out in flow. Prilocaine was synthesised in 74 % overall yield in a 13.6 min residence time for all processes. In chapter three, we demonstrate how continuous flow technology can be exploited to develop synthetic processes towards betrixaban. Synthetic routes towards betrixaban feature two amide bond formation transformations. Pleasingly, we explored multistep chemistry to develop amide synthesis protocols in flow without interruption for work up and isolation. An overall yield of 92 % was achieved to get to key intermediate to betrixaban in 8 min total residence time. Chapter four demonstrates the robustness of developed amide synthesis protocols, a key transformation in synthetic routes towards prilocaine and betrixaban in continuous flow systems. A total of 22 amides were synthesised via flow multistep processes with isolated yields greater than 82 %. All the compounds were characterized using infrared spectroscopy (IR), and nuclear magnetic resonance (NMR). Quantification of the reaction mixtures were carried out using highperformance liquid chromatography (HPLC) and gas chromatography (GC). , Thesis (PhD) -- Faculty of Science, School of Biomolecular & Chemical Sciences, 2024
- Full Text:
- Date Issued: 2024-12